Technology Platform

Our innovative concept is the protein engineering of receptor ligands to generate signalling agonists that modulate the activity of immune cells.

Phage Display
We use our proprietary phage display platform with a built in selection for folding and stability.
Phage Display
Library Design
Highly efficient structure guided protein library design. Optimised library construction methods.
Library Design
Immunology
Immunology
First-hand documented expert knowledge of the mechanisms governing salutary successful versus pathological inflammation.
Disease Models
Disease Models
State-of-the-art in vitro and in vivo models of inflammation-dependent diseases.

Stay tuned for more information on our pipeline.

Publications

  • von Knethen A, et al., Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis. Theranostics. 2019 Mar 16;9(7):2003-2016. doi: 10.7150/thno.28057.
  • Emmerich CH, et al., Improving target assessment in biomedical research: the GOT-IT recommendations. Nat Rev Drug Discov. 2021 Jan;20(1):64-81. doi: 10.1038/s41573-020-0087-3
  • Klöß S, et al.,From Cancer to Immune-Mediated Diseases and Tolerance Induction: Lessons Learned From Immune Oncology and Classical Anti-cancer Treatment. Front Immunol. 2020 Jul 8;11:1423. doi: 10.3389/fimmu.2020.01423./li>
  • Rueschenbaum S, et al., Dysregulated Adaptive Immunity Is an Early Event in Liver Cirrhosis Preceding Acute-on-Chronic Liver Failure. Front Immunol. 2021 Jan 26;11:534731. doi: 10.3389/fimmu.2020.534731/li>